South Africa is set to introduce a groundbreaking HIV prevention method in 2026 that could dramatically alter the country’s approach to combating the epidemic.
The revolutionary drug known as Lenacapavir, requiring just two injections annually, has shown remarkable efficacy in clinical trials and is expected to be rolled out initially in high-risk districts across six provinces, as noted by eNCA.
Health Minister Dr Aaron Motsoaledi announced the planned March 2026 rollout during a national roundtable discussion on the country’s preparedness for the new treatment.
The long-acting injectable represents what health officials describe as a crucial addition to South Africa’s HIV prevention strategy, especially for populations who struggle with current prevention methods.
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Minister Motsoaledi emphasised the transformative potential of the new treatment during his announcement.
‘We need prevention methods that fit into people’s lives, that address the gaps left by existing tools,’ he stated. ‘This is where Lenacapavir comes in as a timely and much-needed innovation to help us overcome the persistent challenges in our HIV/AIDS response, especially when it comes to prevention.’
Clinical trial results presented by the Minister showed what he characterised as extremely effective, with 100% protection among women and 96% protection among men who have sex with men and transgender women. These results position the treatment as a potentially game-changing tool in HIV prevention.
Meanwhile, the George Herald reported that the initial rollout will focus on ’23 high-incident districts across six provinces, targeting approximately 360 high-performing public clinics within these areas.’
Priority will be given to what health authorities identify as key vulnerable populations, including pregnant and breastfeeding women, adolescent girls, female sex workers, and men who have sex with men.
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